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Natural Indigo
Naturalis Indigo
Medicinal Group Heat-clearing and detoxicating medicinal

Dried powder or mass prepared from the leaf or the stem and leaf of Baphicacanthus cusia (Nees) Bremek.、(Fam. Acanthaceae), Polygonum tinctorium Ait. (Fam. Polygonaceae) or Isatis indigotica Fort. (Fam. Cruciferae)

Nature and Flavors salty; cold
Meridian Affinity Liver

To remove heat toxin, cool blood, and relieve convulsion



Part used



Eruptive epidemic diseases; spitting of blood and epistaxis due to heat in the blood, chest pain and hemoptysis; ulcers in the mouth; mumps; pharyngitis, laryngitis; infantile convulsion

Research Findings

  • Refined indigo naturalis extract in oil (Lindioil) is a novel, safe and effective therapy for treating nail psoriasis.[1]
  • Indigo naturalis is a safe, inexpensive, and effective alternative topical treatment for skin and nail psoriasis.[2]
  • Indigo naturalis oil extract appeared to improve nail psoriasis.[3]
  • Topical application of indigo naturalis ointment may be a novel, safe and effective therapy for psoriasis.[4]
  • Topical indigo naturalis ointment was a novel, safe, and effective therapy for plaque-type psoriasis.[5]
  • Oral Qing-Dai (Naturalis Indigo) is effective for inducing remission in patients with moderate ulcerative colitis activity and can be tolerated.[6]


Use with great care in stomach cold



  1. Lin YK, See LC, Huang YH, Chang YC, Tsou TC, Lin TY, Lin NL. ( 2014). Efficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: a randomized, observer-blind, vehicle-controlled trial. Phytomedicine. , 21(7):1015-20. doi: 10.1016/j.phymed.2014.02.013. Epub 2014 Mar 26.
  2. McDermott L, Madan R, Rupani R, Siegel D. (2016). A Review of Indigo Naturalis as an Alternative Treatment for Nail Psoriasis. J Drugs Dermatol , 15(3):319-23.
  3. Lin YK, See LC, Chang YC, Huang YH, Chen JL, Tsou TC, Leu YL, Shen YM. (2011). Treatment of psoriatic nails with indigo naturalis oil extract: a non-controlled pilot study. Dermatology. , 223(3):239-43. doi: 10.1159/000333362. Epub 2011 Nov 3.
  4. Lin YK, Wong WR, Chang YC, Chang CJ, Tsay PK, Chang SC, Pang JH. ( 2007). The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis. Dermatology. , 214(2):155-61.
  5. Lin YK, Chang CJ, Chang YC, Wong WR, Chang SC, Pang JH. (2008). Clinical assessment of patients with recalcitrant psoriasis in a randomized, observer-blind, vehicle-controlled trial using indigo naturalis. Arch Dermatol. , 144(11):1457-64. doi: 10.1001/archderm.144.11.1457.
  6. Sugimoto S, Naganuma M, Kiyohara H, Arai M, Ono K, Mori K, Saigusa K, Nanki K, Takeshita K, Takeshita T, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hisamatsu T, Inoue N, Ogata H, Iwao Y, Kanai T. (2016). Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study. Digestion. , 93(3):193-201. doi: 10.1159/000444217. Epub 2016 Mar 10.
  7. 周柳娟 (1989)。<青黛致接觸性皮炎二例報告>。廣西中醫藥,4。
  8. 張莉、段麗萍、楊衛紅、呂愈敏、林三仁 (2004)。<含青黛成分中藥導致便血的臨床特點及可能致病機制>。胃腸病學和肝病學雜誌,2。

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